Bio-adhesion as well as bio-mineralization and metabolic processes are of essential relevance for oral health and diseases. There are multiple interactions of the oral fluids, microorganisms and the hard and soft tissues. There have been numerous studies on these processes but they offer only information on a certain point of time. The aim of the present project is to adapt and to develop highly sensitive sensors applicable in the challenging oral environment to monitor organic and inorganic molecules in a kinetic manner. This will allow further insights for example in the initiation and progression of dental erosions and caries but will also help to understand and to further develop strategies in preventive dentistry. From the technological point of view, the instantaneous and ubiquitous protein adsorption in the oral cavity has to be considered. From a broader perspective, the oral cavity is an easily accessible model system to test and to develop sensor technology for application in humans and in medical technology. In future, comparable sensors will allow detection of biomarkers for general diseases in a non-invasive manner. Miniaturized sensors based on flexible and biocompatible technologies are promising tools, with capacity for real-time monitoring, that can easily access such cavity. As broadly shown in successful demonstrations in vitro and as wearable electronics with excellent performance for sweat analysis, their implementation in the oral cavity is a new level that can offer new perspectives toward non-invasive diagnostics.