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111. 


Biodegradation and cytocompatibility studies of a triphasic ceramic-coated porous hydroxyapatite for bone substitute applications



A. John, M. B. Nair, H. K. Varma, A. Bernhardt, M. Gelinsky

International Journal of Applied Ceramic Technology 5, 11-19 (2008)

Bone defects due to trauma or disease have led to the need for biomaterials as substitutes for tissue regeneration and repair. Herein, we introduce a porous triphasic ceramic-coated hydroxyapatite scaffold (HASi) for such applications. Interestingly, in the degradation experiments with isotonic buffer, HASi showed a significant release of silica with the disappearance of the tricalcium phosphate phase. Furthermore, the material also exhibited cytocompatibility with cultured bone marrow-derived mesenchymal stem cells of human origin. The material chemistry, together with the favorable cellular characteristics, indicates HASi as a promising candidate for critical-size bony defects, which still remains a formidable clinical challenge in the orthopedic scenario.



doi absolute link10.1111/j.1744-7402.2008.02191.x
online abstract at the publisher site
publisher site (ISSN:1546-542X)
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