Informationen zu Lehrveranstaltungen in Opal / Information about lectures can be found in Opal

Skip to content.

TUD

search  |  internal  |  deutsch
Personal tools
TU Dresden » Faculty of Mechanical Science and Engineering » Institute for Materials Science » Chair of Materials Science and Nanotechnology

For a complete list, check out Google Scholar.

prev/next pubs | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996

[back]


541. 


Graphene, other carbon nanomaterials and the immune system: toward nanoimmunity-by-design



A. Gazzi, L. Fusco, M. Orecchioni, S. Ferrari, G. Franzoni, J. S. Yan, M. Rieckher, G. Peng, M. A. Lucherelli, I. A. Vacchi, N. D. Q. Chau, A. Criado, A. Istif, D. Mancino, A. Dominguez, H. Eckert, E. Vázquez, T. D. Ros, P. Nicolussi, V. Palermo, B. Schumacher, G. Cuniberti, Y. Mai, C. Clementi, M. Pasquali, X. Feng, K. Kostarelos, A. Yilmazer, D. Bedognetti, B. Fadeel, M. Prato, A. Bianco, and L. G. Delogu

J. Phys. Mater. 3 34009 (2020)

Carbon-based materials (CBMs), such as graphene, nanodiamonds, carbon fibers, and carbon dots, have attracted much scientific attention as promising biomedical tools. Following exposure, particularly intravenous injection, these nanomaterials can be recognized by immune cells. Such interactions could be modulated by the different physicochemical properties of the materials (eg, structure, size, and chemical functions), by either stimulating or suppressing the immune response. However, a harmonized cutting-edge approach for the classification of these materials based not only on their physicochemical parameters but also their immune properties was missing. The European Commission-funded G-IMMUNOMICS and CARBO-IMmap projects aimed to fill this gap, developing a functional pipeline for the qualitative and quantitative immune characterization of graphene, graphene-related materials (GRMs), and other CBMs. The goal was to open breakthrough perspectives for the definition of the immune profiles of these materials. Here, we summarize our methodological approach, key results, and the necessary multidisciplinary expertise ranging across various fields, from material chemistry to engineering, immunology, toxicology, and systems biology. G-IMMUNOMICS, as a partnering project of the Graphene Flagship, the largest scientific research initiative on graphene worldwide, also complemented the studies performed in the Flagship on health and environmental impact of GRMs. Finally, we present the nanoimmunity-by-design concept, developed within the projects, which can be readily applied to other 2D materials. Overall, the G-IMMUNOMICS and CARBO-IMmap projects have provided new insights on the immune impact of GRMs and CBMs, thus laying the foundation for their safe use and future translation in medicine.



doi absolute link10.1088/2515-7639/ab9317
online abstract at the publisher site
export BibTeX citation (txt file)
export EndNote citation (ris file)


prev/next 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996

[back]



















































last modified: 2020.12.01 Tue
author: webadmin

contact
Prof. Dr. Gianaurelio Cuniberti
secretariat:
Ms Sylvi Katzarow
phone: +49 (0)351 463-31420
fax: +49 (0)351 463-31422
office.nano@tu-dresden.de
postal address:
Institute for Materials Science
TU Dresden
01062 Dresden, Germany
visitors and courier address:
HAL building
TU Dresden
Hallwachsstr. 3
01069 Dresden, Germany
Max Bergmann Center
TU Dresden
Budapester Str. 27
01069 Dresden, Germany