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TU Dresden » Faculty of Mechanical Science and Engineering » Institute for Materials Science » Chair of Materials Science and Nanotechnology

» presentations   » 2017.03.20

Multiplexed sensing of small molecules with silicon nanowire field effect transistors

Stephanie Klinghammer, Tetiana Voitsekhivska, Clemens Kirschbaum, Larysa Baraban, and Gianaurelio Cuniberti

DPG Frühjahrstagung der Sektion Kondensierte Materie (SKM)

2017.03.20; Dresden, Germany

The simultaneous detection of multiple targets within a single chip on a point-of-care device is attracting great attention within bio- and nanotechnology areas for more than decade[1]. Here, we demonstrate a multiplexed, label-free and real-time detection platform for small molecules like hormones, steroids, and viruses based on silicon nanowire field effect transistors (SiNW FETs). SiNW FETs are connected to a CMOS chip enabling the simultaneous readout of up to 32 FETs [2]. We particularly focus on the sensitive and selective binding of the target cortisol by using aptamers as receptors - allowing high sensitive screenings in more physiological conditions[3]. Finally we show the working principle in form of the biochipboxwhich serves as a portable, electro-microfluidic device facilitating the versatile and reliable detection of multiple samples on only one single sensor device.

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