Skip to content.

TUD

search  |  internal  |  deutsch
Personal tools
TU Dresden » Faculty of Mechanical Science and Engineering » Institute for Materials Science » Chair of Materials Science and Nanotechnology

» presentations   » 2004.03.08-12




Filament depolymerization by motor molecules

G. A. Klein, G. Cuniberti, K. Kruse, and F. Jülicher

Deutsche Physikalische Gesellschaft, AKF Frühjahrstagung 2004
German Physical Society, Spring Meeting 2004


2004.03.08-12; Regensburg, Germany

Motor proteins are specialized molecules which bind to filaments of the cytoskeleton and are able to generate forces. An unusual protein, closely related to kinesin motors is MCAK, which binds to microtubule ends and depolymerizes them [1]. We study the process of MCAK binding to microtubules and subsequent depolymerization using stochastic models. Computer simulations of a one-dimensional hopping model are compared to the mean-field theory of the adopted discrete model. Our theory can explain how molecules accumulate at depolymerizing ends.

[1] A. W. Hunter, M. Caplow, D. L. Coy, W. O. Hancock, S. Diez, L. Wordeman, J. Howard, Mol. Cell. 11, 445-457 (2003); R. Ohi, M. L. Coughlin, W. S. Lane, T. Mitchison, Dev. Cell. 5, 309-321 (2003).



abstract (html)

conference announcement (html)



people| research | teaching | links | internal | home

last modified: 2017.03.27 Mo
author: webadmin

contact
Prof. Dr. Gianaurelio Cuniberti
secretariat:
Ms Sylvi Katzarow
phone: +49 (0)351 463-31420
fax: +49 (0)351 463-31422
office@nano.tu-dresden.de
postal address:
Institute for Materials Science
TU Dresden
01062 Dresden, Germany
visitors and courier address:
HAL building
TU Dresden
Hallwachsstr. 3
01069 Dresden, Germany
Max Bergmann Center
TU Dresden
Budapester Str. 27
01069 Dresden, Germany