Skip to content.


search  |  internal  |  deutsch
Personal tools
TU Dresden » Faculty of Mechanical Science and Engineering » Institute for Materials Science » Chair of Materials Science and Nanotechnology

Friday, 20 October 2006
(at 14:15 in room Phy 4.1.13)
Add to your Google Calendar

Molecular dynamics simulations of neuroglobin - ligand binding and protein dynamics

Stephanus Fengler

Abteilung Biophysik
Universität Ulm

Spectra of carbon monoxide in the interior of heme proteins are dominated by the internal electric field. Peak shifts and splittings are inherent information about binding sites, occupation, barriers and orientation. Additionally, pathways to the heme iron can be identified by temperature dependent rebinding experiments. Because the dipole autocorrelation function is connected with the lineshape of the absorbance spectrum a classical molecular dynamics simulation with a proper chosen CO model was carried out. Here in my work I present an identification of three discovered binding sites within Neuroglobin (Ngb) using CO as molecular probe.

slides (pdf)

Invited by G. Cuniberti (MC seminar)

last modified: 2018.10.24 Mi
author: webadmin