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TU Dresden » Faculty of Mechanical Science and Engineering » Institute for Materials Science » Chair of Materials Science and Nanotechnology

Thursday, 03 December 2009
(at 13:00 in room 115, Hallwachsstr. 3)
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Epigenetic regulation: do not disturb

Louise Chisholm

Department of Cellular & Molecular Immunology
Max Planck Institute for Immunobiology in Freiburg

A fertilised egg can divide and produce many different types of cells depending on the expression of a particular set of proteins. The maintenance of specific transcription patterns throughout the life of a cell and how they are passed onto daughter cells is mediated through epigenetic mechanisms: including DNA methylation, the incorporation of histone variants, and covalent modification of histone tails. The combination of these modifications can affect the nuclear organisation and the transcription of genes, and a perturbation can produce cancer or neurological disorders. During my talk I will present two different examples: (i) the role of the ALF family of proteins in regulating transcription in vivo, and (ii) about investigating the link between the centromere-specific histone variant CENPA and colon-rectal cancer. I have investigated the epigenetic mechanisms by using fly genetics to analyse the role of the ALF family, and by using human cells and microscopy to study the effects of mislocalized CENPA.

Brief Bio:

I studied biochemistry in University of Manchester from 1998 to 2002, which included a year-long research internship at the Mayo Institute of Degenerative Diseases, in Florida, USA. After my bachelors I worked as a research assistant for a year in at Kings College London. In 2003 I moved to University of Oxford to join Professor Kay Davies' laboratory for my PhD to investigate the function of the ALF family. Then in 2007 I started a postdoc fellowship in Dr Heun's laboratory at the Max Planck Institute for Immunobiology in Freiburg am Breisgau, where I studied the histone variant CENPA.

Invited by G. Cuniberti

last modified: 2018.10.24 Mi
author: webadmin