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TU Dresden » Faculty of Mechanical Science and Engineering » Institute for Materials Science » Chair of Materials Science and Nanotechnology



Wednesday, 29 January 2014
(at 15:00 in room Max Bergmann Center Dresden, Budapester Str. 27, Seminar Room Bio, ground floor)
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The mechanical properties of cells and tissues - does soft matter?

Jochen Guck


BIOTEC Dresden
   






While most current biological research focuses on molecular, biochemical aspects of cell function, we are interested in the mechanical properties of cells and tissue and their importance for biological function. The mechanical strength of cells is largely determined by the cytoskeleton, an internal polymer hybrid network intricately regulated by many signaling pathways. This cytoskeleton evolves during physiological changes, such as differentiation, is involved in many cellular functions, such as migration, and is characteristically altered in pathologies, including cancer or inflammation. We can exploit the deformability of the cytoskeleton as a link between molecular structure and biological function to sensitively monitor these functional changes using an optical stretcher. Our findings suggest the use of cell compliance as an integral, inherent cell marker obviating the need for external markers or special preparation. Further, also the mechanical properties of biological tissues are increasingly being recognized as important because cells measure and respond to the mechanics of their environment. We are investigating this mechanosensitivity of neurons and glial cells in the context of development and pathologies of the central nervous system. This research could lead to novel therapeutic approaches in traumatic injuries to the CNS and neurodegenerative disorders.

Brief Bio:



Announcement (pdf)

Invited by G. Cuniberti

Within the nanoSeminar

last modified: 2017.11.15 Mi
author: webadmin

contact
Prof. Dr. Gianaurelio Cuniberti
secretariat:
Ms Sylvi Katzarow
phone: +49 (0)351 463-31420
fax: +49 (0)351 463-31422
office@nano.tu-dresden.de
postal address:
Institute for Materials Science
TU Dresden
01062 Dresden, Germany
visitors and courier address:
HAL building
TU Dresden
Hallwachsstr. 3
01069 Dresden, Germany
Max Bergmann Center
TU Dresden
Budapester Str. 27
01069 Dresden, Germany