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TU Dresden » Faculty of Mechanical Science and Engineering » Institute for Materials Science » Chair of Materials Science and Nanotechnology

Thursday, 20 October 2016
(at 13:00 in room 115, Hallwachsstr. 3)
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3D Micro-Tissue dots

Jerome Bibette

Ecole superieure de physique et de chimie industrielles de la Ville de Paris (ESPCI ParisTech), PSL* Research University, Paris, France

In the human body, each tissue has its own extracellular matrix composition and stiffness and its unique tri-dimensional cell arrangement which makes growing ex-vivo tissues a challenge. Here we show that long term culture (month) within the core of a few hundred microns diameter, porous and scaffold-free, capsules under physiological conditions provides a solution. As one example we show how primary human hepatocytes reorganize inside hydrogel capsules and create a tri-dimensional spheroid by self-assembling over the first week post-encapsulation. Establishment of cell-cell interactions and extracellular matrix deposition lead to formation of micro-tissues that mimic physiological in vivo phenotypes. One attribute are bile canaliculi, an interconnected network playing the role of elimination of bile secreted by hepatocytes, which is perfectly established in our system contrary to 2D cultures. This morphological conformity to liver architecture is also reflected in the high liver-specific metabolic functions detected in our micro-tissues such as high cell viability (up to 45 days) and preservation, as well as a high and stable level of gene expression and enzymatic activity of major liver-specific metabolizing enzymes. We will finally discuss the various potential applications and uses of such technology.

Announcement (pdf)

Brief Bio:

Jerome Bibette, Ph.D. born July 8th 1960, french, is a Professor at Ecole Supérieure de Physique et Chimie Industrielles de la ville de Paris, (ESPCI), from 2001-present, and the Director of the Chemistry Biology Innovations Institute in ESPCI. Major research accomplishments include, i) invented the first route to prepare Brownian monodisperse emulsions, ii) and from these new colloids demonstrated various important interaction and phase transition mechanisms in colloidal science, iii) invented and develop the first technique to directly probe force distance profiles between colloidal particles, iv) developed a general understanding of metastability and coalescence of emulsions, v) developed tools for production as well as a general understanding of controlled emulsification by shear, and applied it to double emulsion and magnetic emulsion large scale preparation. vi) developed new magnetic colloids from emulsion and invented new techniques based on self

Invited by G. Cuniberti

Within the nanoSeminar

last modified: 2021.10.02 Sat
author: webadmin