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TU Dresden » Faculty of Mechanical Science and Engineering » Institute for Materials Science » Chair of Materials Science and Nanotechnology

Thursday, 04 May 2017
(at 13:00 in room 115, Hallwachsstr. 3)
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The Applied Side of Bacillus subtilis - Reprogramming bacterial differentiation to generate functionalized biological microparticles

Prof. Thorsten Mascher

Chair of General Microbiology, Institute for Microbiology, TU Dresden

We are interested in how microorganisms, especially the Gram-positive model bacterium Bacillus subtilis , respond to environmental changes, particularly antibiotic stress. The primary questions that motivate our basic research are: What are the molecular mechanisms of novel signal transducing systems mediating antibiotic resistance (molecular biology)? How do such signal transducing systems interdependent within regulatory networks (systems biology)? How can we rewire such systems to orchestrate novel expression programs within bacteria (Synthetic Biology)? Over the years, the knowledge gained from approaching these central questions has been applied to developing novel genetic tools (e.g. novel expression systems or whole-cell biosensors) or novel concepts, such as SporoBeads. The latter will be the primary focus of this talk. When faced with adverse environmental conditions, B. subtilis forms highly resistant endospores. These dormant life stages are encased in a multi-layered proteineaous shell that contributes to their stability and resistance properties. The formation of these spores is strictly regulated by a spatio-temporal differentiation program. By adapting this native regulation and developing a standardized vector suite for easily generating chimeric genes, we have modified the outermost layer - the crust - to display covalently attached fusion proteins of interest on the spore surface. Thus (enzymatically) functionalized, these SporoBeads can be applied in biotechnological processes, ranging from enzymatic conversions with simplified downstream processing to protein design and evolution.

Announcement (pdf)

Brief Bio:

Thorsten Mascher studied Biology at the Universität Kaiserslautern (Germany) and graduated in 2001. After a postdoctoral stay at Cornell University (US) in the group of John Helmann, he returned to Germany as a research associate in 2004 to start his own junior research group at the Georg-August Universität Göttingen. In 2008, he accepted the position of an independent research group leader at the Karlsruhe Institute of Technology (KIT). A year later, he was appointed as Associate Professor of Synthetic Biology at the Ludwig-Maximilians-Universität (LMU) München. Since 2015, he is now a Full Professor of General Microbiology at the Technische Universität (TU) Dresden. His current research revolves around bacterial signal transduction and gene regulation in Gram-positive bacteria. The aims are (i) understanding how bacteria respond to (antibiotic) stress and (ii) developing genetic tools and approaches to harness the great potential of Bacillus subtilis as a biotechnological workhorse.

Invited by G. Cuniberti

Within the nanoSeminar

last modified: 2021.10.02 Sat
author: webadmin