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TU Dresden » Faculty of Mechanical Science and Engineering » Institute for Materials Science » Chair of Materials Science and Nanotechnology

Friday, 04 May 2007
(at 15:00 in room Phy 5.0.21)
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Photoinduced electron transfer chemistry in DNA

Hans-Achim Wagenknecht

Institut für Organische Chemie
Universität Regensburg

Electron transfer (ET) reactions represent a widespread and exciting research field in chemistry as well as in biology and physics. In particular, the biomacromolecule DNA as an interesting functional -system for molecular electronics and a unique medium for electron transfer has attracted a considerable amount of research efforts. In principle, DNA-mediated charge transfer processes can be categorized as oxidative hole transfer and reductive electron transfer. We focused our work on the spectroscopic and chemical investigation of reductive electron transfer. New photochemical assays consisting of fluorophore-modified oligonucleotides have been synthesized and developed which give new insights into the mechanism of these processes. Currently, an electron hopping mechanism is proposed which involves pyrimidine radical anions as intermediate electron carriers.
[1] H.-A. Wagenknecht (Ed.), Charge Transfer in DNA, Wiley-VCH, Weinheim, 2005.
[2] H.-A. Wagenknecht, Nat. Prod. Rep. 2006, 23, 973-1006.
[3] H.-A. Wagenknecht, Angew. Chem. Int. Ed. 2006, 45, 5583-5585.
[4] H.-A. Wagenknecht, Curr. Org. Chem. 2004, 8, 251-266.
[5] H.-A. Wagenknecht, Angew. Chem. Int. Ed. 2003, 42, 3204-3206.
[6] H.-A. Wagenknecht, Angew. Chem. Int. Ed. 2003, 42, 2454-2460. Research papers:
[3] L. Valis, Q. Wang, M. Raytchev, I. Buchvarov, H.-A. Wagenknecht, T. Fiebig, Proc. Natl. Acad. Sci. 2006, 103, 10192-10195.
[4] C. Wagner, H.-A. Wagenknecht, Org. Lett. 2006, 8, 4191-4194.
[5] C. Wanninger, H.-A. Wagenknecht, Synlett 2006, 2051-2054.
[6] J. Barbaric, H.-A. Wagenknecht, Org. Biomol. Chem. 2006, 4, 2088-2090.
[6] L. Valis, E. Mayer-Enthart, H.-A. Wagenknecht, Bioorg. Med. Chem. Lett. 2006, 16, 3184-3187.
[7] E. Mayer-Enthart, H.-A. Wagenknecht, Angew. Chem. Int. Ed. 2006, 45, 3372-3375.
[8] L. Valis, N. Amann, H.-A. Wagenknecht, Org. Biomol. Chem 2005, 3, 36-38.

Brief Bio:

Prof. Achim Hartschuh studied Physics at the Universities of Tübingen and Stuttgart. After receiving his Ph.D. in 2001 he spent two years as a postdoctoral scientist at the University of Rochester, USA. From 2002 to 2006 he was Juniorprofessor at the Universities of Siegen and Tübingen. Since April 2006 he is Professor for Physical Chemistry at the LMU München. His work is focused on the development and application of novel near-field optical techniques.

Invited by C. Strunk

Within the Graduiertenkolleg Nichtlinearität und Nichtgleichgewicht in kondensierter Materie, GRK 638

last modified: 2021.10.21 Thu
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