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TU Dresden » Faculty of Mechanical Science and Engineering » Institute for Materials Science » Chair of Materials Science and Nanotechnology

Thursday, 14 June 2012
(at 13:00 in room 115, Hallwachsstr. 3)
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Macromolecules and colloids on lipid membranes: Brownian motion, conformational dynamics, and local perturbations

Eugene Petrov

Biophysics lab (Prof. Schwille)
Biotec, TU Dresden

The plasma membrane is one of the most important units of the cell, not only because it defines the boundaries of cell components and the cell itself, but also because of its functionality. The functionality of the membrane is largely determined by the Brownian motion of lipids, membrane proteins, and membrane domains (rafts). Therefore, in order to properly understand the dynamics of membrane processes, one should understand the laws governing the Brownian motion of membrane inclusions. In this context, I will discuss experimental results on translational and rotational diffusion of micrometer-sized solid domains in two-component lipid membranes, as well as the behavior of negatively charged rod-like fd virus particles and DNA macromolecules weakly adhering to freestanding cationic lipid bilayers. I will show that these experimental observations are in a good agreement with the predictions of a hydrodynamics-based theory for the viscous drag on membrane inclusions. Stronger interactions of macromolecules and colloidal particles with lipid membranes can lead to local lipid demixing and curvature perturbations of the membrane. As an example of such a behavior, I will discuss the recently discovered phenomenon of DNA condensation on freestanding cationic lipid membranes.

Brief Bio:

Eugene P. Petrov graduated in 1992 from the Physics Department of the Belarusian State University, Minsk, Belarus. From 1992 till 2001 he worked at the Laser Dyes Lab (Prof. Anatoly Rubinov) and Nanooptics Lab (Prof. Sergey Gaponenko) of the Stepanov Institute of Physics, National Academy of Sciences of Belarus, where he earned a PhD degree for his studies of photophysics of dye molecules and semiconductor quantum dots in various microheterogeneous environments ranging from biological membranes to photonic crystals. In 2002, E. P. Petrov joins for one year the group of Prof. Christian von Borczyskowski at TU Chemnitz to continue his research on photophysical properties of semiconductor quantum dots and organic dye molecules in nanostructured environments. In 2003, E. P. Petrov joins the group of Prof. Petra Schwille at the BIOTEC, TU Dresden, and shifts his research focus to single-molecule biophysics and physics of bio-inspired soft matter. His current research interests include diffusion and phase transitions in lipid membranes, conformational dynamics of biomacromolecules, as well as interaction of (bio)polymers and colloids with lipid membranes.

Invited by G. Cuniberti

Within the nanoSeminar

last modified: 2021.10.21 Thu
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