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TU Dresden » Faculty of Mechanical Science and Engineering » Institute for Materials Science » Chair of Materials Science and Nanotechnology

Thursday, 23 October 2008
(at 13:00 in room 115, Hallwachsstr. 3)
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Shear flow mediated conformational changes of single tethered DNA chains

Katrin Günther

Institute for Materials Science and Max Bergmann Center of Biomaterials
Dresden University of Technology

The micromechanical properties of linear polymer chains such as double-stranded DNA has long been of interest in both life and materials science since many processes in nature and technology involve transport and manipulation of DNA in liquid environment. A novel technique based on attaching a nanometer-sized fluorescent quantum dot (Qdot) specifically to the free end of the native DNA duplex allows its direct observation in flow fields. The thermal fluctuations of single, surface-tethered DNA duplexes have been analysed by fluorescence microscopy. A steady shear flow has been applied in order to stretch the DNA molecule and the positions of the Qdot-labelled end were tracked. From there, the mean fractional extension and the fluctuations parallel and perpendicular to the flow direction were quantified and related to morphological changes.

Invited by G. Cuniberti (nanoSeminar)

last modified: 2021.10.21 Thu
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