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TU Dresden » Faculty of Mechanical Science and Engineering » Institute for Materials Science » Chair of Materials Science and Nanotechnology

Thursday, 20 November 2008
(at 13:00 in room 115, Hallwachsstr. 3)
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A collagen type I/methylcellulose composite material for skin regenerative

Jirut Meesane

Institute for Materials Science and Max Bergmann Center of Biomaterials
Dresden University of Technology

Collagen type I is a major component of the extracellular matrix of human tissue. Because it has desirable properties for biomedical applications, especially biological functionality, it is an attractive material for tissue engineering. Methylcellulose is one kind of polysaccharide which is utilized in many fields. Due to its structure, functionality and properties, it is also used for biomedical applications. The purpose of this work was to evaluate collagen type I / methylcellulose hybrid materials for tissue engineering of skin, based on the concepts of material science: preparation, structure, properties and performance. For the preparation, self-assembly of collagen was observed. The results demonstrate that a sample having methylcellulose as a component can undergo more rapid self-assembly. Structure, morphology, structural ordering, molecular interaction, molecular interaction and mobility were characterized. The sample containing methylcellulose has the morphology of a multilayer fibrous material and it was able to generate less hydration than the sample without methylcellulose. Furthermore, it was found that both collagen type I and methylcellulose can generate molecular interaction. Both residual water and ratio of components had an influence on the molecular mobility of this hybrid material. Concerning physical and mechanical properties, the samples containing methylcellulose as the component had a high swelling ratio and high elongation at break, high tensile strength and high toughness. For biochemical properties, the samples containing methylcellulose had high values of protein binding. Finally, fibroblasts proliferated better on collagen / methylcellulose composite membranes, compared to those made of pure collagen which has demonstrated by LDH and DNA analysis.

slides (pdf)

Invited by G. Cuniberti (nanoSeminar)

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