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TU Dresden » Faculty of Mechanical Science and Engineering » Institute for Materials Science » Chair of Materials Science and Nanotechnology

Tuesday , 18 March 2014
(at 13:00 in room HAL 115)
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Membrane-Spanning DNA Nanopores: Bottom-up Structures for Single-Molecule Research and Nanotechnology

Stefan Howorka

University College London, Department of Chemistry, UK

DNA nanotechnology excels at rationally designing functional bottom-up structures. I describe the design and generation of stable self-assembled DNA-based nanopores that insert into lipid bilayers to support transmembrane water flow. The DNA nanopores consist of a bundle of six hexagonally arranged duplexes which are interconnected by cross-overs. The negatively charged nanobarrels carry lipid anchors to facilitate the pores' insertion into the hydrophobic bilayers. The lipid anchors either neutralize localized negative charges on the DNA backbone (Nano Letters, 2013, 13, 2351) or consist of few, large hydrophobic groups (Angew Chem Int Ed, 2013, 52, 12069). The small membrane-spanning DNA pores merge the fields of nanopores and DNA-nanotechnology and will help open up the design of entirely new molecular devices for applications within single-molecule research and sensing, electric circuits, catalysis, and nanofluidics.

Brief Bio:

2009 Assoc. Prof. in Chemical Biology, UCL Chemistry
2005 Assist. Prof. in Chemical Biology, UCL Chemistry
2001 - 2004 Group Leader Surface Chemistry, UAR GmbH, Linz, Austria
1999 - 2001 Postdoctoral Fellow, Prof. Bayley, Texas A&M University, USA
1998 PhD, University of Vienna, Austria

Announcement (pdf)

Invited by G. Cuniberti

Within the nanoSeminar

last modified: 2021.10.21 Thu
author: webadmin