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TU Dresden » Faculty of Mechanical Science and Engineering » Institute for Materials Science » Chair of Materials Science and Nanotechnology

Tuesday, 22 March 2016
(at 17:00 in room BIOTEC, seminar rooms E05/E06, Broadcasted from Grenoble, France)
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Actin Dynamics, Architecture, and Mechanics in Cell Motility

Laurent Blanchoin

Materials Science Division
Research Director at CNRS, Institute of Life Science CEA

Tight coupling between biochemical and mechanical properties of the actin cytoskeleton drives a large range of cellular processes including polarity establishment, morphogenesis, and motility. This is possible because actin filaments are semi-flexible polymers that, in conjunction with the molecular motor myosin, can act as biological active springs or “dashpots” able to exert or resist against force in a cellular environment. To modulate their mechanical properties, actin filaments can organize into a variety of architectures generating a diversity of cellular organizations. I will describe the feedback loop between biochemical and mechanical properties of actin organization at the molecular level in vitro, I will integrate this knowledge into our current understanding of cellular actin organization and its physiological roles.

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