Taking classes in physics always starts with Newtonian mechanics. In reducing the size of the objects considered however the transition into the quantum mechanical regime has to occur. The 'mechanics' of quantum mechanics is best studied in nano-structured semiconductor systems often termed nano-electromechanical systems (NEMS). I will review recent results on combining single electron devices with NEMS, which are useful as detectors, for limited displacement detection, as well as for measuring single electron-phonon interaction. If time permits, I will branch out into combining NEMS with biological transistors, such as ion channels in cell membranes.