Ultrasensitive label-free detection and quantification of chemical and biological species are crucial to many areas of the life sciences and medicine. Applications are ranging from disease detection and screening of drug molecules to discovery and study of fundamental cellular processes. Silicon semiconductor nanowires configured as field effect transistors have become a general platform for the direct electrical detection of chemical and biological species. The sensor performance can be influence by the doping level and nanowire surface modifications needed to create sensing selectivity. The talk is giving an insight into basic aspects and examples of nanowire sensor systems as well as a brief introduction to the device fabrication based on silicon nanowires grown by the vapor-liquid-solid (VLS) method. The detection of the neurotransmitter dopamine in phosphate buffered saline solution using TiO2 modified nanowires serves as an example to elucidate silicon nanowire sensing in detail.
Ultrasensitive label-free detection and quantification of chemical and biological species are crucial to many areas of the life sciences and medicine. Applications are ranging from disease detection and screening of drug molecules to discovery and study of fundamental cellular processes. Silicon semiconductor nanowires configured as field effect transistors have become a general platform for the direct electrical detection of chemical and biological species. The sensor performance can be influence by the doping level and nanowire surface modifications needed to create sensing selectivity. The talk is giving an insight into basic aspects and examples of nanowire sensor systems as well as a brief introduction to the device fabrication based on silicon nanowires grown by the vapor-liquid-solid (VLS) method. The detection of the neurotransmitter dopamine in phosphate buffered saline solution using TiO2 modified nanowires serves as an example to elucidate silicon nanowire sensing in detail.
