To survive and assemble into multicellular organism, cells need to migrate in specific directions either in order to find nutriments or define polarity axis in biological tissues. Cellular decision-making in defining those direction relies on a complex integration of various types of signals. How cells integrate all these cues in space and time to establish and maintain polarity to perform directed migration is a fundamental but unresolved problem. Using a highly interdisciplinary approach based on our unique joint expertise in light shaping, cellular optogenetics, advanced microscopy and cell mechanics, I will discuss the strategy we developed to probe how living cells deals with signal treatment.
To survive and assemble into multicellular organism, cells need to migrate in specific directions either in order to find nutriments or define polarity axis in biological tissues. Cellular decision-making in defining those direction relies on a complex integration of various types of signals. How cells integrate all these cues in space and time to establish and maintain polarity to perform directed migration is a fundamental but unresolved problem. Using a highly interdisciplinary approach based on our unique joint expertise in light shaping, cellular optogenetics, advanced microscopy and cell mechanics, I will discuss the strategy we developed to probe how living cells deals with signal treatment.