Field-effect transistor (FET) biosensors are highly promising platforms for real-time, label-free detection of biomolecules. Their performance, however, strongly depends on the material used in the sensing channel. MXenes, a class of 2D transition metal carbides and nitrides, offer outstanding electrical conductivity, hydrophilicity, and a chemically versatile surface — making them ideal candidates for next-generation FET biosensors.

This thesis aims to explore the use of MXene-based FETs for the detection of biomolecular targets such as DNA, hormones, or proteins. The student will fabricate MXene-FET devices, functionalize them with recognition elements (e.g., aptamers or antibodies), and evaluate their biosensing performance in buffer and biological fluids.

Research Plan:
Fabrication of MXene-based FETs
Synthesis and characterization of Ti₃C₂Tₓ MXenes
Integration into FET architectures (bottom- or top-gated)
Surface Functionalization for Biosensing
Immobilization of biomolecular probes (DNA, aptamers, antibodies)
Use of PEG or linker chemistry for antifouling and orientation control
Biosensing Experiments
Label-free detection of model analytes (e.g., hormones or nucleic acids)
Sensitivity, specificity, and limit-of-detection measurements
Testing in buffer and/or diluted biological matrices
Data Analysis & Performance Optimization
Electrical characterization of biosensor response
Investigation of response stability, reusability, and device reproducibility
Expectations: The candidate should have interest in nanomaterials, biosensing, and electrical device characterization.
Starting date: ASAP