Multiplexed sensing of small molecules with silicon nanowire field effect transistors


DPG Frühjahrstagung der Sektion Kondensierte Materie (SKM) | event contribution
March 20, 2017 | Dresden, Germany

The simultaneous detection of multiple targets within a single chip on a point-of-care device is attracting great attention within bio- and nanotechnology areas for more than decade[1]. Here, we demonstrate a multiplexed, label-free and real-time detection platform for small molecules like hormones, steroids, and viruses based on silicon nanowire field effect transistors (SiNW FETs). SiNW FETs are connected to a CMOS chip enabling the simultaneous readout of up to 32 FETs [2]. We particularly focus on the sensitive and selective binding of the target cortisol by using aptamers as receptors - allowing high sensitive screenings in more physiological conditions[3]. Finally we show the working principle in form of the biochipboxwhich serves as a portable, electro-microfluidic device facilitating the versatile and reliable detection of multiple samples on only one single sensor device.


Authors

Multiplexed sensing of small molecules with silicon nanowire field effect transistors


DPG Frühjahrstagung der Sektion Kondensierte Materie (SKM) | event contribution
March 20, 2017 | Dresden, Germany

The simultaneous detection of multiple targets within a single chip on a point-of-care device is attracting great attention within bio- and nanotechnology areas for more than decade[1]. Here, we demonstrate a multiplexed, label-free and real-time detection platform for small molecules like hormones, steroids, and viruses based on silicon nanowire field effect transistors (SiNW FETs). SiNW FETs are connected to a CMOS chip enabling the simultaneous readout of up to 32 FETs [2]. We particularly focus on the sensitive and selective binding of the target cortisol by using aptamers as receptors - allowing high sensitive screenings in more physiological conditions[3]. Finally we show the working principle in form of the biochipboxwhich serves as a portable, electro-microfluidic device facilitating the versatile and reliable detection of multiple samples on only one single sensor device.


Authors